Scientists rely on a wide array of cells as experimental models for research
In vitro human cell line models have been widely used for applications such as toxicology, immunology, and cancer pharmacogenomic studies to predict therapeutic efficacy and to identify novel mechanisms associated with variation in drug response. ATCC advanced cell models such as luciferase-labeled cells, isogenic cells, neural progenitor cells, solute transporter carrier cells, and next-generation cell models will ensure your research results are reproducible and verifiable.
Cell models
Isogenic Cells
Clinically relevant cell models are critical for studies of molecular and cellular mechanisms of tumors, as well as for drug screening for cancer. Using genome editing tools such as CRISPR/Cas9, ATCC has created isogenic cell lines with mutants of key oncogenes, which are ideal for identifying novel treatment regimens.
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Luciferase-labeled Cells
Luciferase-labeled cell lines bridge the gap between in vitro and in vivo research for biological mechanism studies and drug development. This advanced model provides a highly sensitive means to measure biological processes in cell-based assays and to assess drug efficacy in live animal models through bioluminescence imaging.
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HCMI cell models
We are continually adding 2-D and 3-D patient-derived cancer models to our portfolio. These next-generation models include both common as well as rare and understudied examples of cancer from numerous tissues.
Immuno-oncology models
Explore our checkpoint luciferase reporter cells, CAR-T target luciferase reporter cells, THP-1 reporter cells, and primary immune cells that support the development of immuno-oncology therapies.
Neural Progenitor Cells
Neural Progenitor Cell (NPC) solutions from ATCC are potent models of normal and disease neurobiology and important tools for investigating neural development, degeneration and regeneration, neurogenetics, neural excitability, nervous system disorders, neurotransmitters, neurotoxicity, and drug screening.
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Solute Transporter Carrier Cells
There is growing demand for in vitro kidney transporter models with normal human renal function. By using well-characterized hTERT-immortalized RPTEC's that stably overexpress the OAT1, OCT2, or OAT3 gene, ATCC created kidney cell models that provide renal tissue-relevant results and predictability for clinical trials.
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